Human Sera
Cayman Chemical ValrocemIde 50mg
An anticonvulsant; protects against MES-, PTZ-, picrotoxin-, or bicuculline-induced seizures in mice (ED50s = 151, 132, 275, and 248 mg/kg, respectively); prevents sound-induced seizures in Frings audiogenic-sensitive mice (ED50 = 52 mg/kg) and MES-induced seizures in rats (ED50 = 73 mg/kg); prevents seizures in corneally kindled rats (ED50 = 161 mg/kg)
Cayman Chemical Josamycn 100mg
A macrolide antibiotic; active against clinical isolates of the Gram-positive aerobic bacteria (MIC50s = ≤0.39 UG/ml for all), as well as Gram-negative anaerobic bacteria at 6.25 UG/ml; increases survival in mouse models of systemic S. aureus, S. pyogenes, and S. pneumoniae infection (ED50s = 206.8, 205, and 86.7 mg/kg, respectively)
Cayman Chemical D-LysIn lactam 100mg
A chiral building block; has been used in the synthesis of a chiral synthetic antibiotic intermediate, as well as in the stereoselective synthesis of NK receptor antagonists
Cayman Chemical Curcuma zdoara Grmacron 100mg
A sesquiterpene with diverse biological activities; inhibits PRV replication in Vero cells from 10-150 µM; enhances doxorubicin-induced cytotoxicity and apoptosis in doxorubicin-resistant MCF-7/adr cells from 50-250 µM; reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity at 5, 10, and 20 mg/kg; decreases brain MDA levels and activity of SOD and GPX, as well as reduces infarct volume in a rat model of MCAO-induced ischemia-reperfusion injury
Cayman Chemical EVP-6124hydrochlorIde 50mg
A partial agonist of α7 subunit-containing nAChRs (IC50 = 22.38 nM); 1,000-fold selective for α7 subunit-containing nAChRs over α4β2 subunit-containing nAChRs at 10 µM, as well as a panel of 60 peptide and nonpeptide receptors, ion channels, and transporters; induces inward currents in Xenopus oocytes expressing human α7 subunit-containing nAChRs (EC50 = 0.16 µM); reverses scopolamine-induced deficits in the novel object recognition task and prevents natural forgetting of a familiar object in rats at 0.1, 0.3, and 1 mg/kg; reduces premature responding in the 5CSRTT in low-attentive female rats
Cayman Chemical FruquIntInIb 100mg
A VEGFR inhibitor (IC50s = 33, 35, and 0.5 nM for VEGFR1, -2, and -3, respectively); inhibits RET, FGFR1, and c-Kit (IC50s = 128, 181, and 458 nM, respectively) in a panel of 253 kinases; inhibits VEGF-A- induced proliferation of HUVECs and VEGF-C-induced proliferation of HLECs (IC50s = 1.7 and 4.2 nM, respectively); decreases tube formation by HUVECs by 74 and 94% at 30 and 300 nM, respectively; reduces tumor growth in BGC-823, HT-29, Caki-1, and NCI H460 mouse xenograft models at 0.5-20 mg/kg per day for 21 days
Cayman Chemical FluphenazInN2chLRoethn 50mg
A derivative of fluphenazine that contains an alkylating chlorethylamine chain, which produces irreversible protein binding; a relatively selective, irreversible antagonist of D2 receptors both in vitro (IC50 = 100 nM) and in vivo; irreversibly inhibits calmodulin at higher doses (IC50 = 10 µM)
Cayman Chemical aDGalactose1phosphatepo 100mg
An intermediate in the interconversion of glucose and galactose
Cayman Chemical EmraclIdIn 50mg
An M4 muscarinic receptor PAM; selective for M4 mAChRs over a panel of 59 receptors, ion channels, transporters, and enzymes at 10 µM; selectively potentiates ACh-induced activation of the M4 mAChR over M1-M3 and M5 mAChRs in cells expressing the human receptors (EC50s = 12.3, 4,798, >10,000, >10,000, and >10,000 nM, respectively); inhibits amphetamine-induced locomotor activity in mice and prepulse inhibition deficits in rats at 3.2 mg/kg
Cayman Chemical BIotInyl hexylamIn 100mg
A synthetic intermediate; has been used in the synthesis of ANANAS and chemotherapeutic conjugates
AdipoGen BioStab Peroxidase Conj Stabil
Horseradish peroxidase HRP is an enzyme commonly used for immunodetection. BioStab Peroxidase Conjugate Stabilizer extends the lifetime of HRP-antibody conjugates and increases the signal intensity, allowing much more consistent results over extended periods of time compared to daily prepared dilutions. BioStab Peroxidase Conjugate Stabilizer can be used in ELISA, Western Blotting, Immunohistochemistry and any other applications which require HRP conjugates. It is supplied as ready-to-use solution for dilution of HRP conjugates. This stabilizer contains a minimum amount of a surfactant and is free of any protein to minimize potential unspecific interactions.
AdipoGen BioStab Antibody Stabilizer
Free or conjugated antibodies are often used in immunoassays, either in the system specific detector antibody plus streptavidin-HRP or in the system analyte-specific antibody plus species-specific antibody-HRP-conjugate. Both systems allow a high flexibility at lower costs. BioStab Antibody Stabilizer dramatically extends the life of your valuable antibodies, allowing much more consistent results over extended periods of time compared to daily prepared dilutions. BioStab Antibody Stabilizer can be used in ELISA, Western Blotting, Immunohistochemistry and any other applications which require marker or biotinylated antibodies. It is supplied as a ready-to-use solution for dilution of antibodies. This stabilizer contains a minimum amount of a surfactant. The stabilizer is free of any protein to minimize potential unspecific interactions. The method below is strongly recommended for standard assay procedures and reduces loss of valuable conjugates and assay-to-assay variations.
Sigma Aldrich Fine Chemicals Biosciences SigMatrix Ultra Serum Dilu
for more information on other Sigmatrix products visit the Sigmatrix Selection Guide.
